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Biohacking

Data-driven physiological optimization — wearables, protocols, and the clinical research behind what actually moves your biomarkers.

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Oct 16updated
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Healthy Aging: Why Exercise Is Non-Negotiable and Protein Is Supporting Cast

New research reframes the protein-first aging model. Exercise is the irreducible core of healthy aging — protein helps, but it doesn't replace what movement does at the cellular level.

· 3 min

Protein Restriction for Kidney Disease: What the Evidence Actually Shows

Peter Attia reviews the MDRD trial and Cochrane data: the default CKD advice to restrict protein lacks the evidence base it's been given — and the biggest trial showed higher long-term mortality in the restriction group.

· 3 min

Aging Research Has Been Studying the Wrong Sex

The Reproductive Resilience Hypothesis, published in Cell, argues female biology holds the key to understanding longevity — but most aging research has treated it as experimental noise.

· 2 min

One Shot, Five Organs: FGF21 Gene Therapy Extends Mouse Healthspan by 20%

A single AAV injection of FGF21 extended median lifespan by over 20% in aged mice, protecting liver, kidneys, heart, muscle, and brain — and it worked after age-related decline had already begun.

· 2 min

Human Longevity's $599 Genomics for All: What Clinical-Grade DNA Sequencing Gets You Now

Human Longevity sequences all 6.4 billion base pairs at $599 — and an AI layer re-alerts you as science evolves. What it covers, who it's actually for, and why the re-analysis matters more than the price.

· 3 min

The Bathroom as a Longevity Clinic: What Vivoo's Passive Monitoring Stack Changes

Vivoo's urinalysis platform and toilet-integrated hydration monitor embed daily biomarker collection into existing routines. What it covers, why passive beats active testing, and where this sits in a complete longevity stack.

· 3 min

NMR Blood Testing: One Blood Sample, Four Different Risk Scores

A single NMR blood scan reveals heart disease, insulin resistance, inflammation, and mortality risk — the inventor explains why one draw beats a standard panel.

· 3 min

Metabolic Health: Why GLP-1s Were Never the Whole Answer

GLP-1 drugs sparked the metabolic health boom, but the platforms building around it are betting the real product is what happens after the prescription.

· 3 min

Niagen's NR Study: A 2.5-Year Drop in Muscle Epigenetic Age

A new peer-reviewed analysis links NR supplementation to a 2.5-year reduction in muscle epigenetic age — though the funding company calls the data preliminary.

· 3 min

Living Near a Data Center Without Wrecking Your Sleep

Data centers bring measurable noise, EMF, heat, and air exposure to nearby homes. A practical framework for measuring and mitigating each risk.

· 4 min

Timeline Wins $5.3M Judgment Against Fake Urolithin A Sellers

A federal court awarded Timeline $5.3M and permanent injunctions against 19 counterfeit urolithin A sellers — a case that signals the longevity supplement market is finally getting real enforcement.

· 2 min

Ultrahuman's Emerald Update Answers a Question Wearables Kept Ignoring

Ultrahuman's Emerald overhaul replaces spreadsheet-style metrics with a decision engine that tells you what to actually do next — plus a VO2 max algorithm validated to lab-grade accuracy.

· 3 min

Peter Attia's Framework for Environmental Threats to Longevity: Air, Noise, and Light

AMA #87 applies Attia's 80/20 principle to chronic environmental exposures — PM2.5, noise, and artificial light — and which interventions actually move the longevity needle.

· 3 min

Heat Training Boosts Hemoglobin — But Can It Make You Faster?

Heat training reliably raises hemoglobin mass by 2–5%. But 5 of 6 trials find no clear performance payoff in VO₂max or sport results. Here's what the evidence actually shows.

· 3 min

Dumbo Health Is Turning Sleep Into a Clinical Longevity Metric — Here's What That Means

Miami-based Dumbo Health launched Sleep Longevity: 51 blood biomarkers, wearable data, and physician care in one membership. The 90% of women with undiagnosed sleep apnea are the real target.

· 3 min

Scientists Reversed 'Permanent' Aging Damage in Human Tissue. Here's What Was Fixed.

A Nature Communications study showed an engineered enzyme (CMLase) removed advanced glycation end products from human arterial, skin, and lens tissue — reversing damage long considered irreversible.

· 3 min

Google's SensorFM: What a 1-Trillion-Minute Wearable Dataset Changes

Google's new foundation model for wearable sensors outperformed prior models on 34 of 35 health tasks — and what it means for the future of passive health monitoring.

· 3 min

Does Losing Sleep Mean Losing Lifespan? What the Meta-Analysis Can't Tell You

A new 79-study meta-analysis links short sleep to 14% higher mortality — but Peter Attia identifies a fundamental problem with the data. Here's what the observational evidence actually proves, and what the controlled research says instead.

· 3 min

The $10 Billion Probiotic Problem: What the Evidence Shows and What Works Instead

The probiotic market generates $10 billion per year despite evidence that most commercial supplements don't persist in the gut. Here's what the studies say—and five mechanistically stronger alternatives.

· 3 min

Dry Fasting for 5 Days: What the Biometrics Actually Showed

A measured 5-day dry fast tracked with continuous glucose, ketones, HRV, InBody scans, and grip strength. What the data showed — and what the dehydration artifact gets wrong.

· 3 min

99% of Probiotics Don't Colonize Your Gut. Here's What Actually Works.

The probiotic supplement market is projected to hit $10 billion by 2028 — and the evidence suggests most products fail to deliver meaningful gut benefits. A breakdown of what the science actually says and five evidence-backed alternatives to consider.

· 3 min

RLT Home TotalSpectrum Panels: Lab-Tested 7-Wavelength Review (2026)

A spectrometer test of RLT Home's ELITE panel measured 70.75 mW/cm² irradiance and 0.7 mG EMF at 12 inches, strong numbers for a full-body panel.

· 3 min

Home Infrared Sauna Buying Guide: The Three Specs That Actually Matter

The infrared sauna market spans $200 blankets to $15,000 cabins. Most buyers choose wrong by focusing on wood and aesthetics. Three specs determine whether a unit delivers results.

· 3 min

Fountain Life's $595 BASE Plan Is the Longevity Industry's Mass-Market Moment

Fountain Life's new BASE membership brings 100+ biomarkers, DEXA scan, and AI-guided clinician review to individuals for $595 — a significant shift from its ultra-premium roots.

· 2 min

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